Salazopyrin Tablets

Therapeutic indications
Induction and maintenance of remission of ulcerative colitis; treatment of active Crohn's Disease.

Posology and method of administration
The dose is adjusted according to the severity of the disease and the patient's tolerance to the drug, as detailed below.

Elderly Patients
No special precautions are necessary.

A) Ulcerative colitis
Adults

Severe Attacks
Salazopyrin 2-4 tablets four times a day may be given in conjunction with steroids as part of an intensive management regime. Rapid passage of the tablets may reduce effect of the drug.

Night-time interval between doses should not exceed 8 hours.

Moderate Attack
2-4 tablets four times a day may be given in conjunction with steroids.

Maintenance Therapy
With induction of remission reduce the dose gradually to 4 tablets per day. This dosage should be continued indefinitely since discontinuance even several years after an acute attack is associated with a four fold increase in risk of relapse.

Children
The dose is reduced in proportion to body weight.

Acute Attack or Relapse
40-60mg/kg per day

Maintenance Dosage
20-30mg/kg per day

Salazopyrin Suspension may provide a more flexible dosage form.

B) Crohn's Disease
In active Crohn's Disease, Salazopyrin should be administered as in attacks of ulcerative colitis (see above).

For Ful Data Sheet go to: https://www.medicines.org.uk/emc/product/3838/smpc